The Boston Circulatory Arrest Study: Antecedents and Correlates of Well-Being in Adults With Cong… (NCT03073122) | Clinical Trial Compass
CompletedNot Applicable
The Boston Circulatory Arrest Study: Antecedents and Correlates of Well-Being in Adults With Congenital Heart Disease
United States127 participantsStarted 2017-11-09
Plain-language summary
In the landmark Boston Circulatory Arrest Study, neurologic and developmental status was measured following infant heart surgery and then prospectively at ages 1, 2.5, 4, 8, and 16 years, with findings of significant neurocognitive deficits and brain MRI abnormalities regardless of operative management. To date, no study has evaluated the neuropsychological and neuroimaging antecedents and correlates of well-being in adults with congenital heart disease, a population now \>1 million and projected to grow at 5% per year. The investigators propose to study the Boston cohort at ages 24-29 years to assess the associations of adult well-being with childhood and adolescent executive function, other measures of mental health and cognitive function, adolescent brain MRI findings, and clinical variables; findings will guide the design of interventions in childhood to optimize outcomes in adults with congenital heart disease.
Who can participate
Age range24 Years – 33 Years
SexALL
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Inclusion criteria
✓. Prior participation in the Boston Circulatory Arrest Study
✓. Informed consent
Exclusion criteria
✕. Disorders that would prevent successful completion of the planned study testing (severe developmental impairment to prevent answering surveys and participating in interviews)
✕. Participants lack of reading fluency in English, which is the only language for which we have the ability to do neuropsychology testing, and for which questionnaires have been validated
✕. Women who are currently pregnant will be excluded from the MRI portion of the study only
✕. Age 24-30 years at the time of enrollment
✕. Informed consent
✕. Conditions that would prevent successful completion of the planned study testing (MRI) (e.g., pacemaker, metal implants, orthodontia)