Remote Ischaemic PreConditioning (RIPC) in Partial Nephrectomy for the Prevention of Ischemia/Rep… (NCT03068689) | Clinical Trial Compass
CompletedNot Applicable
Remote Ischaemic PreConditioning (RIPC) in Partial Nephrectomy for the Prevention of Ischemia/Reperfusion Injury
Switzerland40 participantsStarted 2017-12-01
Plain-language summary
"Remote Ischaemic PreConditioning" (RIPC) is performed prior to partial nephrectomy. Postoperative calprotectin dynamics and Blood Oxygen-Level-Dependent (BOLD) MRI are used to to demonstrate the potential renoprotective effect of RIPC
Who can participate
Age range18 Years – 99 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Informed Consent as documented by signature (Appendix Informed Consent Form)
* Kidney tumor (any entity, benign, malign)
* Partial nephrectomy (any surgical technique, open, retroperitoneoscopic, transperitoneal, Da Vinci assisted)
* 18 years of age
* Sufficient perfusion of all 4 extremities
* palpable distal pulses: A. radialis and A. dorsalis pedis or A.tibialis post.
Exclusion Criteria:
* Women who are pregnant
* Significant peripheral arterial disease affecting upper and/or lower limbs or history of
* Significant renal disease (GFR \<15 ml/min/1.73m2) or undergoing haemodialysis
* Concomitant therapy with glibenclamide or nicorandil (due to potential inference with RIPC)
* Urothelial cancer
* Acute Urinary tract infection
* international normalized ratio (INR) \>2 (haematoma risk at cuff site)