Late Effects After Treatment in Patients With Previously Diagnosed High-Risk Neuroblastoma (NCT03057626) | Clinical Trial Compass
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Late Effects After Treatment in Patients With Previously Diagnosed High-Risk Neuroblastoma
United States376 participantsStarted 2017-06-05
Plain-language summary
This research trial studies late effects after treatment in patients with previously diagnosed high-risk neuroblastoma. Studying late effects after treatment may help to decide which treatments for high-risk neuroblastoma are better tolerated with less side effects over time.
Who can participate
Age range5 Years ā 50 Years
SexALL
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Inclusion Criteria:
* Patients must have been enrolled on COG neuroblastoma biology study ANBL00B1
* Patient must have been diagnosed with high-risk neuroblastoma per ANBL00B1 definition
* Patient must have been diagnosed on or after January 1, 2000
* At least 5 years must have elapsed since diagnosis
* Patients must have been treated for high-risk neuroblastoma
* Note: patients may have had any therapy for high-risk neuroblastoma, including second line or non-established therapies (for example in the setting of less than optimal initial response or concerns for high risk of relapse); patients may have received therapy for refractory or relapsed neuroblastoma, or treatment for an SMN; however all cytotoxic anti-neuroblastoma therapy should have been administered \>= 2 years of the enrollment date; SMN therapy may be completed or ongoing at the time of enrollment
Exclusion Criteria:
* Patients must not be currently receiving active anti-neuroblastoma cytotoxic chemotherapy
* Patients must not have received anti-neuroblastoma cytotoxic chemotherapy within the last two years
* Note: cytotoxic therapies include (but are not limited to) chemotherapy (platinum agents, alkylators, anthracyclines, topoisomerases, vinca alkaloids, other cytotoxic chemotherapy), any kind of transplant, MIBG therapy, and/or radiation therapy
* Non-cytotoxic (biologic/targeted/differentiating/other) therapies are permitted at the time of enrollment; for example, patients receiving oral differeā¦