CompletedNot Applicable

Skeletal Muscle Atrophy and Dysfunction Following Total Knee Arthroplasty

United States23 participantsStarted 2017-01-01

Plain-language summary

Total knee replacement, or arthroplasty, is the final clinical intervention available to relieve pain and functional limitations related to advanced stage knee osteoarthritis. Despite its beneficial effects, the early post-surgical period is characterized by the erosion of lower extremity muscle size and strength that cause further disability and slow functional recovery. While the detrimental effects of this period on muscle are widely recognized, the mechanisms underlying these adaptations are poorly understood and there are currently no widely-accepted clinical interventions to counter them

Who can participate

Age range50 Years – 75 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * symptomatic, primary knee osteoarthritis (OA) * being considered for total knee arthroplasty Exclusion Criteria: * knee OA secondary to inflammatory/autoimmune disease * untreated/uncontrolled hypertension, diabetes or thyroid disease * chronic heart failure, actively-treated malignancy, exercise-limiting peripheral vascular disease, stroke or neuromuscular disease * body mass index \>38 kg/m2 * lower extremity blood clot or known coagulopathies * implanted pacemaker/ICD

What they're measuring

Cross-sectional Area (CSA) of Muscle Fibers

Timeframe: Baseline and 5-weeks post-TKA surgery

Intermyofibrillar Mitochondrial Content

Timeframe: Baseline and 5-weeks post-TKA surgery

Maximal Calcium-activated Tension Single Muscle Fiber Tension

Timeframe: Baseline and 5-weeks post-TKA surgery

Trial details

NCT IDNCT03051984

SponsorUniversity of Vermont

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-06-30

Results submitted2025-07-09

View on ClinicalTrials.gov More Knee Osteoarthristis trials