Menopausal Sleep Fragmentation and Body Fat Gain

Inclusion Criteria: * Healthy premenopausal women 18-45 years old * Regular sleep schedule * Limited alcohol and caffeine intake * Regular monthly menstrual cycles * No lifetime history of hot flashes * Willingness to use approved methods of contraception during study * Not obese * Good general health Exclusion Criteria: * Contraindication, hypersensitivity or previous adverse reaction to gonadotropin releasing hormone agonists * Pregnancy * Breastfeeding * Tobacco use * Contraindicated systemic hormone medications or centrally active medications * Shift workers or recent/expected time zone travel * Obstructive sleep apnea * Insomnia symptoms * Diagnosis of osteoporosis or osteopenia * Hypothalamic-pituitary-adrenal axis disorders * Diabetes * Gastric bypass, metabolic disorders, or other related conditions * Abnormalities on screening laboratory tests * Substantial hearing impairment * Cardiovascular illness * Neurological illness * Recent psychiatric illness or substance-use disorder