This randomized phase I/II trial studies the best dose and side effects of durvalumab and to see how well it works with or without lenalidomide in treating patients with cutaneous or peripheral T cell lymphoma that has come back and does not respond to treatment. Monoclonal antibodies, such as durvalumab, may interfere with the ability of cancer cells to grow and spread. Drugs used in chemotherapy, such as lenalidomide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving durvalumab and lenalidomide may work better in treating patients with cutaneous or peripheral T cell lymphoma.
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CTCL specific response assessed by Lugano Classification
Timeframe: Up to 12 months
Dose limiting toxicity assessed by CTCAE version 4.03
Timeframe: Up to 84 days
Duration of Complete Response
Timeframe: Date when criteria for CR first met until time of loss of CR (relapse/recurrence) or death (as a result of MF/SS or acute toxicity of treatment), assessed up to 12 months
Event-Free Survival
Timeframe: From date of first dose of study drug to first documented disease relapse, progression or death from any cause, whichever occurs first, assessed up to 12 months
Incidence of adverse events assessed by National Cancer Institute CTCAE version 4.03
Timeframe: Up to 90 days post-treatment
Overall Response Rate (ORR)
Timeframe: Up to 12 months
Overall survival (OS)
Timeframe: From date of first dose of study drug to date of death from any cause, assessed up to 12 months
Progression Free Survival (PFS)
Timeframe: Date of initiation of treatment to first date meets criteria for progressive disease or death as a result of any cause, assessed up to 12 months
Response duration
Timeframe: From the date of first documented response to the date of first documented disease relapse, progression or death whichever occurs first, assessed up to 12 months
Time to response
Timeframe: Date of initiation of treatment to date when criteria for response (PR or CR) first met, assessed up to 12 months