CO-Rebreathing in Comparison to Isotopic Red Cell Volume Determination in the Diagnosis of Primit… (NCT03008642) | Clinical Trial Compass
CompletedNot Applicable
CO-Rebreathing in Comparison to Isotopic Red Cell Volume Determination in the Diagnosis of Primitive and Secondary Polycythemia
France60 participantsStarted 2019-04-01
Plain-language summary
The optimized CO-Rebreathing is an efficient method to evaluate the red cell mass and has been used in the vast majority of studies in sport medicine. However, this method has never been evaluated on a large scale in the diagnosis of primitive or secondary polycythemia. The standard procedure to evaluate the red cell mass is based on isotopic measurement using Cr51-labelled red cells, but its lack of availability in many centers highlights the need for a non-invasive and rapid alternative method. The purpose of this study is to evaluate and validate the CO-Rebreathing method in this set of indications.
Who can participate
Age range18 Years – 80 Years
SexALL
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Inclusion criteria
✓. Adult patient
✓. Informed consent obtained
✓. Requirement of an isotopic red cell mass determination:
✓. No recent vascular event (\<6 mois)
✓. No unstable coronaropathy
✓. Non smoking since 24 hours.
✓. ECOG \<2
✓. Negativity of pregnancy test/effective contraception for childbearing age women,