Reversal of the Antiplatelet Effects of Ticagrelor in Combination With Aspirin, Using Normal Platelets

Inclusion Criteria: * Healthy subjects * At least 18 years of age * No history of cardiovascular disease * Not taking antiplatelet therapy prior to participation Exclusion Criteria: * Known thrombocytopenia, other coagulation disorder such as von Willebrand's disease, haemophilia * Allergy or intolerance to ticagrelor or aspirin (if known) * Consumption of drugs within the preceding fourteen days that potentially can interfere with metabolism of ticagrelor through CYP3A4, CYP3A or P-glycoprotein (eg, ketoconazole, clarithromycin, nefazodone, ritonavir, atazanavir, diltiazem, amprenavir, aprepitant, erythromycin, fluconazole, verapamil, rifampicin, dexamethasone, phenytoin, carbamazepine, phenobarbital, cyclosporine, simvastatin, atorvastatin, tolbutamide, digoxin)21 * Previous transfusion or pregnancy (because of potential alloimmunisation) * Pregnant or trying to conceive, or breastfeeding * Unable or unwilling to give written informed consent