Accelerated Hypofractionated vs. Conventionally Fractionated Concurrent CRT for LS-SCLC

Inclusion Criteria: * Histologically or cytologically confirmed SCLC. * Male or female, aged 18-70 years. * ECOG performance status 0 to 2. * Limited-stage SCLC was defined as disease confined to one hemithorax and hilar,mediastinal, or supraclavicular nodes without pleural effusion, which can be safely encompassed within a tolerable radiation field. * No prior thoracic RT. * Weight loss in six months less than or equal to five percent. * FEV1 greater than 0.75L. * No severe internal diseases and no organ dysfunction. * No prior history of any tumor. * Skin test of CT contrast agents was negative. * Had received 1-6 cycles of VP16 plus DDP/carboplatin. * Voluntarily participated in this study and signed the informed consent form by himself or his agent. Had good compliance with the study procedures, and can cooperate with the relevant examination, treatment and follow-up. Exclusion Criteria: * Other tumor history(Except skin cancer/breast cancer/oral cancer/cervical cancer with expected lifespan more than or equal to 3 months). * Multiple primary lung cancer. * Any unstable systemic disease, including active infection, uncontrolled high blood pressure, unstable angina, newly observed angina pectoris within the past 3 months, congestive heart failure (New York heart association (NYHA) class II or higher), myocardial infarction onset six months before included into the group, and severe arrhythmia, liver, kidney, or metabolic disease in need of drug therapy. Human immunodefi…