Danvatirsen and Durvalumab in Treating Patients With Advanced and Refractory Pancreatic, Non-Small Cell Lung Cancer, and Mismatch Repair Deficient Colorectal Cancer

Inclusion Criteria: * The patient/legal representative must be able to read and understand the informed consent form (ICF) and must have been willing to give written informed consent and any locally required authorization (e.g., Health Insurance Portability and Accountability Act in the United States of America \[USA\]; European Union Data Privacy Directive in the European Union \[EU\]) before any study-specific procedures, including screening evaluations, sampling, and analyses * Has a histological confirmation of pancreatic cancer, mismatch deficient colorectal cancer, or non-small cell lung cancer (NSCLC) that is refractory to standard therapy or for which no standard of care regimen currently exists * Has an Eastern Cooperative Oncology Group (ECOG) performance score (PS) score of 0 or 1 * Has measurable disease, defined as at least 1 lesion that can be accurately measured in at least 1 dimension (longest diameter to be recorded) with a minimum size of 10 mm by computerized tomography (CT) scan, except lymph nodes which must have minimum short axis size of 15 mm (CT scan slice thickness no greater than 5 mm in both cases). Indicator lesions must not have been previously treated with surgery, radiation therapy, or radiofrequency ablation unless there is documented progression after therapy * Transfusions intended to elevate any parameters below solely for the intent of meeting study eligibility are not permitted * Leukocytes \>= 3000 mcL * Absolute neutrophil count \>= 15…