CompletedNot Applicable

Wide Spectrum Investigation of Stroke Outcome Disparities on Multiple Levels (WISSDOM)

United States87 participantsStarted 2015-10

Plain-language summary

This research project will evaluate the relationship between cardiovascular risk factors, degrees of physical and mental activity prior to the stroke, brain tissue integrity, post-stroke community participation and neurological recovery after the stroke. Investigators will recruit and study healthy and post stroke participants, gaining insight into the possible mechanisms that explain why the adverse risk profile, which is more commonly present in African-Americans than non-Hispanic Whites in the stroke belt, is translated into a less favorable recovery post stroke.

Who can participate

Age range40 Years – 75 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 40-75 years * prestroke mRS score \>2 * African American or White * Reside in Berkeley, Charleston, Dorchester, Colleton or Georgetown Counties * Ischemic stroke involving only one hemisphere * Fugl Meyer score \>16 at baseline or Aphasia Quotient in Western Aphasia Battery \<93 * no contraindications to research MRI Exclusion Criteria: * Primary or secondary intracerebral hematoma, or subarachnoid hemorrhage, or subdural/ epidural hematoma; Prisoner; diagnoses of substance addiction (alcohol or illicit drugs) * Bihemispheric acute ischemic strokes; * Other concomitant neurological disorders, such as brain tumor, abscess or spinal cord disease affecting language or limb motor function; * Documented history of dementia prior to index event; * Patient suffered one or more recurrent stroke during the 12-month follow up period. * Terminal illness with life expectancy ≤ 1 year * Currently pregnant * Brain stem strokes

What they're measuring

Stroke Specific Quality of Life Scale

Timeframe: 3, 6, 12 months

Stroke Impact Scale

Timeframe: 3, 6, 12 months

NIH Stroke Scale

Timeframe: 0, 3, months

Trial details

NCT IDNCT02982278

SponsorMedical University of South Carolina

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-06-30