Prefrontal Cortical Engagement Through Non-Invasive Brain Stimulation in Schizophrenia (NCT02975973) | Clinical Trial Compass
CompletedNot Applicable
Prefrontal Cortical Engagement Through Non-Invasive Brain Stimulation in Schizophrenia
United States15 participantsStarted 2016-11
Plain-language summary
Cognitive impairments in schizophrenia are the most debilitating aspect of the illness and poorly treated by current medications. This study investigates transcranial direct current stimulation (tDCS) - a safe, noninvasive weak electrical current delivery to stimulate brain function - as a novel therapeutic for cognition in schizophrenia. Integrating neurostimulation, electrophysiology and neuroimaging, this project aims to study tDCS effects on cognition by verifying therapeutic target engagement, evaluating the tolerability of tDCS sessions, and optimizing treatment parameters.
Who can participate
Age range18 Years – 35 Years
SexALL
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Inclusion criteria
✓. ages 18-35 years;
✓. within first five years of antipsychotic treatment;
✓. on stable doses of antipsychotic medication for at least one month;
✓. Clinically stable as defined by Clinical Global Impression-Severity scale (CGI-S) less than or equal to 4 (moderately ill);
✓. Mild to severe cognitive impairment in MATRICS Consensus Cognitive Battery (composite scores \<40);
✓. DSM-5 MINI 7.0.2 criteria for schizophrenia or schizoaffective by patient SCID
Exclusion criteria
✕. Mental retardation as defined by pre-morbid IQ by Wechsler Test of Adult Reading at screening \<70 or Spanish Word Accentuation Test;
✕. significant head injury;
✕. History of severe medical or neurological illnesses
✕. pregnancy or postpartum (\<6 weeks after delivery or miscarriage);
What they're measuring
1
tDCS Engagement of DLPFC Activity Indexed by fMRI BOLD Imaging
Timeframe: 1 week
2
tDCS Engagement of DLPFC Activity Indexed by Modulation of Frontal Cortical Gamma Oscillations