Activates Charcoal for Patients Undergoing Invasive Procedure Delayed Due to Direct Oral Anticoagulants

Inclusion Criteria: * Patients under direct oral anticoagulant treatment (Apixaban, Rivaroxaban or Dabigatran) * Age ≥18 years; * Clinical condition needing a surgery or invasive procedure ( lumbar puncture, biopsy...), needing anticoagulant treatment interruption and intervention to be postponed * Signed informed consent Exclusion Criteria: * Urgent immediate surgery without any possibility to wait for 24 hours * contraindication for receiving oral treatment * Active uncontrolled bleeding or bleeding in critical organ * Hemodynamic instability, shock * Known anticoagulant concentration \< 50ng/mL * drug intoxication * Fructose intolerance, glucose and galactose malabsorption syndrome, sucrase-isomaltase deficit * Treated epileptic disease * Pregnant or breast feeding * Patient under guardianship * No insurance cover * Patient unable to give his consent * Participation to another therapeutic trial