Evaluation of Dentinal Fluid for the Presence of Matrix Metalloproteinase 9 (MMP-9) in Pulpal Inf… (NCT02967081) | Clinical Trial Compass
CompletedNot Applicable
Evaluation of Dentinal Fluid for the Presence of Matrix Metalloproteinase 9 (MMP-9) in Pulpal Inflammation
Switzerland67 participantsStarted 2016-10
Plain-language summary
The purpose of this study is to determine whether dentinal fluid (tooth fluid) of teeth with or without a painful inflammatory condition in their nerve (pulp) contain inflammatory marker.
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria:
Adult patients who attend the University of Zurich, Center of Dental Medicine, Clinic of Preventive Dentistry, Periodontology and Cariology that are in need for
* Treatment of pain related to pulpal inflammation
* Caries therapy
* Root canal treatment of a pulp-necrotic tooth
* Replacement of an defect/fractured filling
Exclusion Criteria:
* Children or adolescents (≤18 y)
* Patients who do not agree to participate in the study
* Patients with general diseases of inflammatory nature (such as diabetes, Crohn's disease, etc), or diseases affecting the immune-system (immuno-suppression, multiple morbidities, etc.)
* Women with known pregnancy
* Patients not fluent in German or English language
* Patients who had antibiotic or NSAID intake during the last 14 days
* Patients who refuse to be examined radiographically.
What they're measuring
1
Total matrix metalloproteinase 9 (MMP-9) level in dentinal fluid