CompletedNot Applicable

Social Cognition and Personality Changes in Alzheimer's & Parkinson's Disease & Frontotemporal Lobar Degeneration

Canada120 participantsStarted 2013-01

Plain-language summary

The aim of this study is to compare personality and social cognition changes, including emotion detection and self-awareness, and neuroanatomical correlates in patients, and how that affects the caregiver-patient relationship.

Who can participate

Age range50 Years – 90 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Patients: * ability to speak and understand the English language (as questionnaires and tests are only available in English) Caregivers: * primary caregiver for a given patient * ability to speak and understand the English language (as questionnaires and tests are only available in English) Exclusion Criteria: Patients and Caregivers: * history of another neurological disorder * psychiatric disorder * severe aphasia (semantic word loss) * visual deficits requiring correction beyond the use of eyeglasses or contact lenses (intact visual acuity is required for completing both the questionnaires and the emotion evaluation test which consists of video vignettes) * auditory deficits requiring correction beyond hearing aids (videos have auditory component) Patients: * presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin or body will be excluded as they will be unable to have a MRI scan. * premenopausal women will be excluded due to the unknown risk of MRIs during pregnancy.

What they're measuring

Personality via the Interpersonal Adjectives Scales and differences between AD, PD, and FTLD

Timeframe: one time visit, through study completion of 3 years

Personality via the Behaviour Inhibition/Approach Scale (BIS/BAS) and differences between AD, PD, and FTLD

Timeframe: one time visit, through study completion of 3 years

Personality via the Big Five Inventory (BFI) and differences between AD, PD, and FTLD

Timeframe: one time visit, through study completion of 3 years

Social cognition via Social Norms Questionnaire and differences between AD, PD, and FTLD

Timeframe: one time visit, through study completion of 3 years

Social cognition via Interpersonal Reactivity Index (IRI) and differences between AD, PD, and FTLD

Timeframe: one time visit, through study completion of 3 years

Social cognition via Revised Self-Monitoring Scale (RSMS) and differences between AD, PD, and FTLD

Timeframe: one time visit, through study completion of 3 years

Social cognition via Social Behaviour Observer Checklist and differences between AD, PD, and FTLD

Trial details

NCT IDNCT02964611

SponsorUniversity Health Network, Toronto

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2016-08-16

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