Very Low Nicotine Content Cigarettes and E-Cigarettes in Promoting Smoking Cessation in Daily and Intermittent Cigarette Smokers

Inclusion Criteria: * Sign consent and agree to all study procedures * Have an address where he/she can receive mail * Have a device available to conduct telehealth visit (e.g., smartphone, computer, tablet, internet access, etc.) * Able to follow verbal and written instructions in English * Willing and able to complete two spirometry sessions (this criterion waived during COVID-19 pandemic) * Be the only participant in their household * Interested in trying novel nicotine products * Daily smokers: \>= 1 cigarette/little cigar per day * Intermittent smokers: \>= 1 cigarette/little cigar per day 4 to 27 days per month * Agrees to comply with all MD Anderson institutional policies related to COVID-19 screening prior to each in-person research visit * The individual agrees to not engage in study procedures or interactions with study personnel while operating a vehicle Exclusion Criteria: * Unwilling to refrain from other e-cigarette use for the duration of the study, other than what is provided to them for study purposes * Current/recent use of certain medications: * Smoking cessation meds (past 90 days; e.g., wellbutrin, bupropion, Zyban, nicotine replacement therapy \[NRT\], Chantix) * Certain medications to treat depression (last 14 days; e.g., amitriptyline) * A case by case determination will be made by study physician for medication on the precautionary list, (e.g. nitroglycerin) * Self-reported daily use of opioids for 30 days or more on phone screen or at scr…