Trial in Adult Participants With Spinocerebellar Ataxia (SCA)

Key Inclusion Criteria: * Participants with a known or suspected diagnosis of the following specific hereditary ataxias: SCA1, SCA2, SCA3, SCA6, SCA7, SCA8 and SCA10 * Ability to ambulate 8 meters without assistance (canes and other devices allowed) * Screening total Scale for the Assessment and Rating of Ataxia (SARA) score ≥8 * Score of ≥ 2 on the gait subsection of the SARA * Determined by the investigator to be medically stable at baseline/randomization and must be physically able and expected to complete the trial as designed Key Exclusion Criteria: * Any medical condition other than one of the hereditary ataxias specified in the inclusion criteria that could predominantly explain or contribute significantly to the participants symptoms of ataxia * Mini Mental State Exam (MMSE) score \< 24 * SARA total score of \> 30 points at screening * Clinical history of stroke * Active liver disease or a history of hepatic intolerance to medications that in the investigator's judgment, is medically significant