Anxiety and Reward Interaction and Prediction of Outcomes in Anorexia Nervosa (NCT02948452) | Clinical Trial Compass
CompletedNot Applicable
Anxiety and Reward Interaction and Prediction of Outcomes in Anorexia Nervosa
United States66 participantsStarted 2015-11
Plain-language summary
This study is designed to understand responsiveness to reward in adolescents with restricting-type anorexia nervosa compared with non-clinical controls, and how it is affected by potential-threat perception.
Who can participate
Age range12 Years – 19 Years
SexFEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria for AN participants:
* Clinical diagnosis of Anorexia Nervosa, Restricting Type within the previous 6 months, (except for the amenorrhea criteria)
* completed treatment in an inpatient, residential, or partial hospitalization program (2-5 times/week) consisting of psychotherapy and dietary monitoring, within the previous 3 weeks
* May be unmedicated, or be taking a serotonin reuptake inhibitor medication at a stable dose for at least 8 weeks at the time of enrollment.
Exclusion criteria for AN participants:
* lifetime Axis I bipolar disorder, lifetime psychotic disorders, lifetime attention deficit hyperactivity disorder, or current post-traumatic stress disorder.
* current substance abuse or dependence, including nicotine
* pathological gambling, as assessed with the South Oaks Gambling Screen
* current neurological disorder
* pregnancy
* current major medical disorders that may affect cerebral metabolism such as diabetes or thyroid disorders
* current risk of suicide with a plan and intent
* a Children's Depression Rating Scale Revised (CDRS-R) score \>75 or major depressive disorder with psychotic features
* ferromagnetic metal implantations or devices (electronic implants or devices, infusion pumps, aneurysm clips, metal fragments or foreign bodies, metal prostheses, joints, rods or plates)
* adjusted BMI ≥ 25 (overweight)
* visual acuity worse than 20/35 for each eye as determined by Snellen close vision chart. Acuity may be met with corrective lens…
What they're measuring
1
Blood oxygen level dependent (BOLD) percentage signal change as measured by fMRI in anxiety and reward brain regions of interest
Timeframe: within 3 weeks of discharge from an intensive treatment program