Non-interventional Study With NOVOCART® Inject in the Reconstruction of the Knee Cartilage Defects

Inclusion Criteria: * male and female patients * juvenile patients with closed epiphysial plate * insulated full-thickness cartilage damage of the knee Joint, ICRS (International Cartilage Repair Society) grade 3-4 * defect size ≥ 2.5 and ≤ 10 cm2 * intact or reconstructed bony subchondral plate * in the case of deep bony substance defects, additional bony reconstruction is needed Exclusion Criteria: * radiographic signs of osteoarthritis of Kellgren and Lawrence \> 2 * joint stiffness * arthrofibrosis * malalignment in the knee (valgus- or varus deformity) \> 3° (correction contemporary to the ACT) * insufficient reconstructed ligaments (correction contemporary to the ACT) * defective position patella (correction contemporary to the ACT) * sled prosthesis implants or carbon pin * inflammatory joint diseases (f.e. rheumatoid arthritis) * corresponding cartilage defects ("kissing lesions") * more than two independent cartilage defects in one knee * primary cartilage reconstructive treatment in children and juvenile with open epiphysial plate * diffuse chondromalacia * congenital or gained deformity of patella