Effect of Continuous Apomorphine During the Night on Sleep Disorders in Insomniac Patients With Parkinson's Disease

Inclusion Criteria: * Idiopathic Parkinson's disease ( Hughes AJ et al. 2001) * Patients with motor fluctuations * Chronic Insomnia disorder criteria according to the criteria of DMS- V ( American Psychiatric Association, 2013) and insomnia severity index \> 15 * Able to use independently the device required for treatment by apomorphine * Collection of written informed consent (legal obligation for any project under the public health law , bioethics laws and / or CNIL) . * Affiliate to social security or beneficiary of such a regime Exclusion Criteria: * Atypical Parkinsonian Syndromes * Parkinson's disease with dementia (Montreal Cognitive Assessment (MoCA) \<25/30 (NASREDDINE and al., 2012)) * Parkinson's disease with hallucinations * Parkinson's disease with impulse Control disorder (ICD) * Parkinson's disease already treated with APOMORPHINE pump or justifying the use of the pump continuously day and night * Another obvious severe disease explaining insomnia * Exclusion for monitoring difficulties (mutation, insufficient motivation, priority associated pathology in care) * Patient unwilling to accept a pump * Patient not accepting polysomnography and multiple sleep latency test * Patient with health problems or a skin disease precluding continuous subcutaneous infusion * Female parturient or nursing * Cardiac dysrhythmia precluding treatment with domperidone or apomorphine (increased QTc ≥ 440 ms in men, QTc ≥ 450 ms in women) * Treatments forbid…