Single Cell Genomics of Psoriatic Skin (NCT02929745) | Clinical Trial Compass
CompletedNot Applicable
Single Cell Genomics of Psoriatic Skin
United States16 participantsStarted 2016-07-01
Plain-language summary
The purpose of this study is to understand how genetics play a role in psoriasis. Specifically, a genetic allele HLA-Cw6 is known to be associated with psoriasis, and this study aims to find out how it affects genetic and protein expression in patients with psoriasis, compared to healthy people, at a single-cell level using a novel flow cytometry and RNA-sequencing protocol.
Who can participate
Age range18 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Ability to provide written consent and comply with the protocol
✓. At least 18 years of age
✓. Diagnosis of plaque psoriasis for at least 6 months prior to enrollment
✓. BSA \> 5% and at least one target plaque on trunk or extremities greater than 10cm2
✓. Ability to provide written consent and comply with the protocol
✓. At least 18 years of age
✓. No previous diagnosis of psoriasis or other inflammatory skin conditions
Exclusion criteria
✕. Subject has non-plaque form of psoriasis.
✕. Subject has drug-induced psoriasis.
✕. Pregnancy at any point during the study period.
✕. Known allergy to lidocaine, other local anesthetics, or any component of local anesthetic agents.
✕. Known HIV positive status.
✕. Evidence of abnormality of any immune cell population from a drug-induced or genetic cause.
✕. Known coagulopathy.
✕
What they're measuring
1
Determination of immune cell population from skin biopsies