Ixazomib Citrate, Lenalidomide, and Dexamethasone in Treating Patients With POEMS Syndrome

Inclusion Criteria: * POEMS syndrome requiring therapy, previously treated or untreated * Plasma vascular endothelial growth factor (VEGF) \> 2 x upper limit of normal (ULN) * Presence of a plasma cell clone (any of the following): * Monoclonal protein in the serum or urine * Measurable light chains by free light chain assay * Measurable plasmacytoma * Monoclonal plasma cells in bone marrow * Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0, 1, 2, or 3 * Absolute neutrophil count (ANC) \>= 1000/uL obtained =\< 14 days prior to registration * Platelet count (PLT) \>= 75,000/uL obtained =\< 14 days prior to registration * Total bilirubin =\< 2.0 mg/dL unless due to known Gilbert's disease obtained =\< 14 days prior to registration * NOTE: If total bilirubin is \> 2 mg/dL, a direct bilirubin should be performed and must be \< 1.5 mg/dL for Gilbert's to be diagnosed * Alanine aminotransferase (ALT/serum glutamic pyruvic transaminase \[SGPT\]) and aspartate aminotransferase (AST, serum glutamic oxaloacetic transaminase \[SGOT\]) =\< 3 x upper limit of normal (ULN) obtained =\< 14 days prior to registration * Creatinine clearance \>= 30 mL/min/1.73 m\^2 (as determined by Cockcroft-Gault equation) obtained =\< 14 days prior to registration * Negative serum pregnancy test done =\< 7 days prior to registration, for women of childbearing potential only * NOTE: Females of reproductive potential must adhere to the scheduled pregnancy testing as required…