This Phase IIa study is designed to assess the safety, tolerability and pharmacokinetics of oral MP1032 in patients with moderate to severe psoriasis over a period of 6 weeks. Secondary endpoints to evaluate clinical parameters for psoriasis during the 6 week treatment period and a 4-week follow up will provide an opportunity to perform a first assessment of oral MP1032's clinical efficacy in the treatment of moderate to severe psoriasis. The study population will consist of 44 enrolled (40 completed) patients with moderate to severe chronic plaque psoriasis. Patients must be able to provide written consent and meet all the inclusion criteria and none of the exclusion criteria.
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Safety - Treatment Emergent Adverse Events (TEAEs) - Number of TEAEs
Timeframe: Continuously from Treatment Start until the last follow-up visit on Study Day 71
Safety - Treatment Emergent Adverse Events (TEAEs) - Number of Related TEAEs by SOC
Timeframe: Continuously from Treatment Start until the last follow-up visit on Study Day 71
Safety - Treatment Emergent Adverse Events (TEAEs) - Number of Patients With TEAEs
Timeframe: Continuously from Treatment Start until the last follow-up visit on Study Day 71
Safety - Treatment Emergent Adverse Events (TEAEs) - Number of Patients With Related TEAEs by SOC
Timeframe: Continuously from Treatment Start until the last follow-up visit on Study Day 71
Pharmacokinetics (PK) - Plasma Concentrations
Timeframe: Study Days 1, 15, 29 and 43
Pharmacokinetics (PK) - Maximum Observed Concentration (Cmax)
Timeframe: Study Day 1
Pharmacokinetics (PK) - Time
Timeframe: Study Day 1
Pharmacokinetics (PK) - Area Under the Curve (AUC)
Timeframe: Study Day 1
Pharmacokinetics (PK) - Area Under the Curve (AUC) - Subgroups
Timeframe: Study Day 1