Throat and Other HPV-Related Cancers in Men: Identifying Them Early

Inclusion Criteria: * Stage 1 Inclusion Criteria: United States (US) resident * Stage 1 Inclusion Criteria: Fluent in English * Stage 1 Inclusion Criteria: Sign an approved informed consent document * Stage 2 (longitudinal study) Inclusion Criteria: * Eligible for and enrolled in Stage 1 * Test positive to HPV16 E antibodies; be identified as a negative control; test positive for oral HPV16 infection by oral rinse; or test positive for cvDNA * Sign an approved informed consent document Exclusion Criteria: * Stage 1 Exclusion Criteria: Patients with previously documented squamous cell carcinoma of the oropharynx, anus, or penis * Stage 1 Exclusion Criteria: Received radiation cancer therapy to the head and neck in the past * Stage 1 Exclusion Criteria: On active cancer therapy now or in the past 6 months * Stage 1 Exclusion Criteria: Ever had a transplant (stem cell, bone marrow, or solid organ) * Stage 1 Exclusion Criteria: Patients who received blood transfusions in the last 6 months * Stage 1 Exclusion Criteria: Other medical or psychiatric illness or social situation that would limit study compliance * Stage 2 (longitudinal study) Exclusion Criteria: Any seronegative and cvDNA-negative man who tests negative for oral HPV16 DNA by swab and oral rinse at two consecutive follow-up visits will be excluded from further follow-up. Any man who is seropositive, cvDNA-positive, or has evidence of integration at any time will continue to be followed regardless of oral HPV1…