Genetics of Response to Canagliflozin

Inclusion Criteria: * Of Amish descent * Age 18 or older * BMI: 18-40 kg/m2 Exclusion Criteria: * Known allergy to canagliflozin * History of diabetes, random glucose greater than 200 mg/dL, or HbA1c greater than or equal to 6.5% * Currently taking diuretics, antihypertensive medication uric acid lowering medications, or other medication that the investigator judges will make interpretation of the results difficult * Significant debilitating chronic cardiac, hepatic, pulmonary, or renal disease or other diseases that the investigator judges will make interpretation of the results difficult or increase the risk of participation * Seizure disorder * Unwilling to go off of vitamin supplements and over the counter medication (except for acetaminophen) for at least two weeks prior to the first home visit and agree to avoid these medications for the duration of the study. * Positive urine human chorionic gonadotropin test or known pregnancy within 3 months of the start of the study * Estimated glomerular filtration rate less than 60 mL/min * Currently breast feeding or breast feeding within 3 month of the start of the study * Liver function tests greater than 2 times the upper limit of normal * Hematocrit less than 35% * Abnormal thyroid hormone stimulating hormone