Swallowable Sponge Cell Sampling Device and Next Generation Sequencing in Detecting Esophageal Cancer in Patients With Low or High Grade Dysplasia, Barrett Esophagus, or Gastroesophageal Reflux Disease

Inclusion Criteria: * Ability to understand and the willingness to sign a written informed consent document * Patients must be scheduled for a procedure capable of providing a definitive pathologic diagnosis and evaluating for complications of the esophageal sponge on the same day as the study procedure, either upper endoscopy or surgical esophagectomy * One of the following inclusion criteria must be true for patient to be eligible for enrollment: * Subjects with known esophageal cancer (adenocarcinoma or squamous cell carcinoma) * Subjects with a history of low or high grade dysplasia * Subjects with risk factors for esophageal malignancy including Barrett?s esophagus and gastroesophageal reflux disease (GERD) Exclusion Criteria: * Subjects that are unable to swallow a tablet/pill * Subjects with completely obstructing esophageal cancer * Subjects with known or suspected esophageal varices * Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements * Any condition which, in the opinion of the investigator precludes the patient from completion of the study procedure