Immunologic Profile of Chronically Photodamaged Skin

Inclusion Criteria: * Male or female * Subject is at least 18 years of age * Good general health * No disease states, physical conditions or medications that would impair evaluation of the test sites * Willingness and ability to follow protocol * Signed, written, and witnessed informed consent form * Subject to have either severe clinical photodamage or no clinical photodamage * If female, subjects who are either of non-childbearing potential (defined as post-menopausal-absence of menstrual bleeding for 1 year - or as having undergone bilateral tubal ligation, hysterectomy or bilateral oophorectomy), or, if of childbearing potential, subjects who have had a negative urine pregnancy test at the beginning of the study, and have agreed to practice appropriate birth control to prevent pregnancy during the study. The type and dose of birth control must have been stable for at least 3 months prior to study entry and not be expected to change during the study. Exclusion Criteria: * Current tanning bed use or phototherapy * Individuals who have lidocaine sensitivity * Subjects with severe allergies manifested by a history of anaphylaxis, or history of presence of multiple severe allergies * Subjects with a history of asthma * Subjects on topical or systemic antihistamine therapy * Subjects on tricyclic antidepressant therapy * Subjects on beta-blocker medications * Subjects on any immunosuppressive therapy * Subjects with active inflammation or infection on the skin * Subjects wit…