CompletedNot Applicable

Analysis of Immune Response In Bacterial Infection of Obese Subject

France15 participantsStarted 2014-08

Plain-language summary

Improve knowledge of the immune response to sepsis in obese patients. Define immunological and genetic prognostic factors of severe infections which can motivate a change in the therapeutic attitude

Who can participate

Age range

18 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * between18 and 80 years * obesity: BMI \> 30 * presumed bacterial infection: * pneumonitis (documented or probably) * pyelonephritis / acute prostatitis * soft tissue / skin infection (except for bedsore) * cholecystitis / angiocholitis * meningitis * clostridium colitis * surgical site infection * signed consent Exclusion Criteria: * patients with viral, parasitic or mycotic documented infection * patients with bacterial infection with treatment\> 4 weeks (ex. endocarditis; osteo- articular infections) * patients with prior antibiotic treatment (\< 14 days) * intensive care unit patients * patients with a history of cancer or malignant hematological disease within the 5 previous years that is currently clinically significant (non metastatic prostatic and basocellular malignancy are excluded) * patients with systemic disease * Known diagnosis of human immunodeficiency infection (DICV, HIV…) * immunosuppression treatment during last month including corticotherapy * pregnancy * 3 months follow up not possible * non signed consent

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Patterns of inflammatory and immunological markers in obese patients in sepsis and post- sepsis ("normal") situation

Timeframe: T 0 and at 1 month

Trial details

NCT IDNCT02882568

SponsorVersailles Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-02

View on ClinicalTrials.gov More Obesity trials

Who can participate

Age range

18 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.