Human Menopausal Gonadotropin Combining With Human Chorionic Gonadotropin Treat Congenital Hypogonadotropic Hypogonadism

Inclusion Criteria Criteria A * Boy \>14yr without any sign of puberty, testis \<4ml * BA ≥12yr * Sex hormone (LH,FSH, T) are pre-pubertal level * No other hormones problems (other pituitary glands axis are normal except gonad axis) * No space occupying lesion, No tumor on MRI of pituitary and hypothalamus area * Kallmann's syndrome(KS) patients may companies with dysosmia or dysplasia of olfactory bulb or olfactory tract on MRI * Karyotype is 46，XY * Exclude chronic diseases, malnutrition Criteria B * For the boy \<14yr. who companies with micropenis or cryptorchid or hypospadias and they have anosmia or dysplasia of olfactory bulb/olfactory sulcus/olfactory structs on MRI include in. Criteria C * As the phenotype of hypogonadotropic hypogonadism are variant, some of them may have partial puberty. So, we enrolled them when they have testis volume \>4ml or the testosterone level \>200ng/L，companies anosmia or dysplasia of olfactory bulb /olfactory sulcus/ olfactory structs on MRI, and the puberty arrested in half a year. These patients can be diagnosed as Kallmann Syndrome. Exclusion Criteria: * Any ascertain reason contributes to the non puberty development (Chromosome abnormal, trauma, surgeries) or any ascertain disease such as Prader-Willi syndrome or hypergonadotropic hypogonadism * Systemic diseases (such as chronic kidney failure, Mediterranean anemia, poor controlled diabetes) * Protein-energy malnutrition * Eating disorder (such as anorexia nervosa, binge eat…