MMV390048 POC in Patients With P. Vivax and P. Falciparum Malaria

Inclusion Criteria: * Body weight between 40 kg and 90 kg inclusive * Presence of P. vivax or P. falciparum monoinfection confirmed by: * Fever, as defined by axillary temperature ≥37.5°C or oral/rectal/tympanic temperature ≥38°C, or history of fever in the previous 48 hours for P. vivax and 24 hours for P. falciparum and, * Microscopically confirmed parasite infection: 1,000 to 40,000 asexual parasite count/µL blood * Written informed consent provided by the patient in accordance with local practice. If the patient is unable to write, witnessed consent is permitted according to local ethical considerations. * Ability to swallow oral medication * The patient is able to understand and comply with protocol requirements, instructions and protocol-stated restrictions and is likely to complete the study as planned * Willing to be hospitalized for at least 72 hours or until malarial parasites are not detected by microscopy on 2 consecutive occasions whichever comes later and return to clinic for all follow-up visits * Women must be of non-childbearing potential (WNCBP) as per one of the following definitions: * postmenopausal defined as having age-appropriate, natural (spontaneous) amenorrhea for at least 12 months prior to screening in the absence of an alternative medical cause for the amenorrhea, or * premenopausal with irreversible surgical sterilization by hysterectomy and/or bilateral oophorectomy or salpingectomy at least 6 months prior to screening (as determined by subjec…