To determine the optimal dosing regimen and route of administration of tranexamic acid (TXA) \[single dose intravenous (IV), double dose intravenous, intravenous + topical, and oral repeated dosing\] to minimize post-operative blood loss and transfusion requirements following revision total knee arthroplasty (RTKA).
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Post-operative reduction in Hemoglobin
Timeframe: Post-operative and before discharge from hospital (inpatient), < 30 days from surgery
Post-operative reduction in Hematocrit
Timeframe: Post-operative and before discharge from hospital (inpatient), < 30 days from surgery
Calculated blood loss
Timeframe: Post-operative and before discharge from hospital (inpatient), < 30 days from surgery
Number of units transfused
Timeframe: Post-operative and before discharge from hospital (inpatient), < 30 days from surgery
Number of Patients Transfused
Timeframe: Post-operative and before discharge from hospital (inpatient), < 30 days from surgery