Anemia Studies in Chronic Kidney Disease: Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor Daprodustat-Non-Dialysis (ASCEND-ND)

Inclusion Criteria: * Age: 18 to 99 years of age (inclusive) * CKD stage: Kidney Disease Outcomes Quality Initiative (KDOQI) CKD stages 3, 4, or 5 defined by electronic eGFR using the CKD Epidemiology Collaboration (CKD-EPI) formula. * Erythropoietin-stimulating agents (ESAs)/Hgb: Group 1 (not using ESAs): No ESA use within the 6 weeks prior to screening and no ESA use between screening and randomization (Day 1). Group 2 (ESA users): Use of any approved ESA for the 6 weeks prior to screening and continuing between screening and randomization. * For Group 1 (not using ESAs), Hgb concentration at Week -8 and Week 1 should be 8 to 10 gram per deciliter (g/dL). For Group 2 (ESA users), Hgb concentration at Week -8 should be 8 to 12 g/dL and at Week 1 should be 8 to 11 g/dL. * \>=80% and \<=120% compliance with placebo during run-in period. * Informed consent (screening only): capable of giving signed informed consent which includes compliance with the requirements and restrictions. Exclusion Criteria: * Dialysis: On dialysis or clinical evidence of impending need to initiate dialysis within 90 days after study start (Day 1). * Kidney transplant: Planned living-related or living-unrelated kidney transplant within 52 weeks after study start (Day 1). * Ferritin: \<=100 nanograms (ng)/milliliter (mL) (\<=100 micrograms/liter \[L\]) at screening. * Transferrin saturation (TSAT) (screening only): \<=20%. * Aplasias: History of bone marrow aplasia or pure red cell aplasia. * Other ca…