High Flow Nasal Oxygen Versus VNI in Acute Hypercapnic Cardiogenic Pulmonary Edema (NCT02874339) | Clinical Trial Compass
UnknownNot Applicable
High Flow Nasal Oxygen Versus VNI in Acute Hypercapnic Cardiogenic Pulmonary Edema
France250 participantsStarted 2016-10-26
Plain-language summary
The purpose of this study is to determine whether high flow nasal oxygen (HFNO) therapy is non inferior to non invasive ventilation (NIV) in the immediate treatment of patients with acute hypercapnic cardiogenic pulmonary edema associated with respiratory failure in the emergency department.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria:
* Asuspected diagnosis of acute pulmonary edema presenting with any of the following criteria:
* Dyspnea (orthopnea or a worsening of dyspnea according to NYHA criteria)-Respiratory rate \>20 b/min
* Bilateral crepitant rales at pulmonary auscultation
* Pulmonary infiltrate on chest X-ray
* Signs of respiratory failure or any of the following clinical, laboratory or or radiology signs:
* Use of accessory respiratory muscles
* Paradoxical abdominal movement
* Cardiomegaly (cardiothoracic ratio \>0.5)
* Hypertensive crisis
* PaO2/FiO2 \<= 300 mmHg breathing O2\> 8L/min or PaO2 \<= 63mmHg breathing room air.
* Hypercapnia (PaCO2\>45)
Exclusion criteria:
* Chronic respiratory disease or associated dyspnea from non cardiac origin,
* Fever (\>38,5°), sepsis or ongoing infection,
* Contra-indication to NIV,
* Treatment with NIV or CPAP prior to inclusion, including prehospital treatment