UnknownNot Applicable

Pubertal Induction in Individuals With Hypogonadism

United Kingdom24 participantsStarted 2016-09

Plain-language summary

The investigators wish to explore the variability of uterine, breast and bone outcome markers as surrogates to assess the adequacy of exogenous oestrogen replacement in individuals with hypogonadism.

Who can participate

Age range10 Years – 30 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Have a diagnosis of hypogonadism (Turner's syndrome, hypogonadotrophic hypogonadism, primary ovarian insufficiency, hypopituitarism, hypothalamic amenorrhoea, transgender)
✓. ≥ 10 years of age
✓. Oestrogen naïve i.e. no prior commencement of oestrogen treatment
✓. Breast Tanner stage ≤ than 2

Exclusion criteria

✕. Previous oncology treatment
✕. Primary amenorrhoea secondary to chronic medical comorbidity
✕. PCOS diagnosis

What they're measuring

Uterine dimensions and volume

Timeframe: Assessment every 2 months for a total of 8 months

Trial details

NCT IDNCT02871986

SponsorUniversity College, London

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2018-03

Contact for this trial

Gerard Conway, FRCP, MD

02073809101 g.conway@ucl.ac.uk

View on ClinicalTrials.gov More Primary Amenorrhoea trials