Vision Restoration With a Collagen Crosslinked Boston Keratoprosthesis Unit

Inclusion Criteria: * Willing and able to provide written informed consent * Willing and able to comply with study assessments for the full duration of the study * Age ≥ 18 years * Candidate for a Boston Keratoprosthesis / Cornea transplant * In generally good stable overall health * Patients with an eye at risk for a cornea sterile ulcer which includes: * Autoimmune diseases (mucus membrane pemphigoid, Stevens-Johnson syndrome, systemic lupus erythematosis, rheumatoid arthritis, or other autoimmune diseases); OR * History of previous sterile cornea ulceration requiring a cornea transplant Exclusion Criteria: * Age \< 18 years * Inability to provide written informed consent and comply with study assessments for the full duration of the study * No or minimal tear production with evidence of keratinization of the bulbar conjunctiva * Corneal or ocular surface infection within 30 days prior to study entry * Ocular or periocular malignancy * Inability to wear a contact lens due to lid abnormalities or shortened fornix * Signs of current infection, including fever and current treatment with antibiotics * Pregnancy (positive pregnancy test) or lactating * Participation in another simultaneous interventional medical investigation or trial