A Study Evaluating the Effects of Topical Clitoral Estradiol Cream in Post Menopausal Women

Inclusion Criteria: * Sexually active postmenopausal women of any age with complaint of vulvar and/or vaginal atrophy who also complain of bothersome decreased libido, and/or arousal, and/or orgasmic dysfunction Exclusion Criteria: * Not sexually active with a partner or an arousal device * Uncontrolled diabetes as defined by having a consistent blood sugar level of over 100 mg/dL * Uncontrolled hypertension as defined by an average systolic blood pressure ≥140 mmHg or an average diastolic blood pressure ≥90 mmHg, among those with hypertension * Allergic to estradiol * Contraindications to estradiol such as undiagnosed abnormal genital bleeding; known/suspected or history of breast cancer; known/suspected estrogen-dependent neoplasm; active deep vein thrombosis, pulmonary embolism; active or recent stroke or myocardial infarction; liver dysfunction or disease * Spanish speaking