The Effects of tDCS on Illness Awareness in Schizophrenia (NCT02848885) | Clinical Trial Compass
CompletedNot Applicable
The Effects of tDCS on Illness Awareness in Schizophrenia
Canada32 participantsStarted 2016-08
Plain-language summary
This is a novel study that seeks to explore the clinical and functional imaging effects of transcranial direct current stimulation (tDCS) on illness awareness or anosognosia in schizophrenia, arguably the most treatment-resistant manifestation of the disorder.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Male or female inpatients or outpatients ≥ 18 years of age
✓. Having a DSM-IV diagnosis of schizophrenia or schizoaffective disorder
✓. Voluntary and capable of consenting to participation in the research study
✓. Fluent in English
✓. Moderate-to-severe lack of illness awareness (≥3 on PANSS G12 Insight and Judgment item)
✓. On a stable dose of antipsychotic and other concomitant medications, and unlikely to undergo changes in dose during the study
Exclusion criteria
✕. Serious unstable medical illness or any concomitant major medical or neurological illness, including a history of seizures or a first degree relative with a history of a seizure disorder
✕. Acute suicidal and/or homicidal ideation
✕. Formal thought disorder rating of over 2 on the (Scale for Assessment of Positive Symptoms) SAPS.
✕. DSM-IV substance dependence (except caffeine and nicotine) within one month prior to entering the study
✕. Pregnant women
✕. Mild lack of insight to good illness awareness (\<3 on PANSS G12 Insight and Judgment item).
✕. Positive urine drug screen for drugs of abuse
What they're measuring
1
Illness awareness
Timeframe: At baseline and weekly for 4 weeks after tDCS