Background: Sights, sounds, and smells can be associated with alcohol and tempt people to drink. The connection between encountering cues and wanting to drink might be reduced by behavioral techniques, like giving the cues at certain times, in certain circumstances. Objective: To see if visual imagery and behavioral techniques can reduce alcohol craving and drinking. Eligibility: Healthy people ages 21 to 65 years old who are mildly concerned about their drinking and have had these habits in the past 3 months: * Women: More than three (3) drinks any single day or more than seven (7) drinks per week * Men: More than four (4) drinks any single day or more than 14 drinks per week Design: * Participants will be screened with medical history, physical exam, blood tests, alcohol breath tests, hepatitis tests, and alcohol and drug use questionnaires. * Participants will get a smartphone to carry throughout the study. They will use it to report on their drinking, moods, and activities daily. The phone's global positioning system (GPS) will record their locations throughout each day. * There will be six (6) study visits approximately over four (4) weeks. Visits will last up to four (4) hours, but the final visit may last up to seven (7) hours. Visits include the following: * Not drinking alcohol or using illicit or over-the-counter drugs at least 24 hours before each visit * Providing urine and breath samples. * Exposure to various cues: Participants' reactions will be monitored by measuring heart rate, blood pressure, and skin temperature. * Drinking alcohol or soft drinks: For visits with alcohol, transportation to and from the visit will be provided. * About a month after the last visit, participants will be called to ask about their drinking and cravings.
Age range
21 Years – 65 Years
Sex
ALL
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Change in Self-reported Alcohol Craving in the Laboratory Sessions
Timeframe: Up to 75 minutes during trial sessions
Self-reported Alcohol Craving in the Laboratory Sessions - Reinstatement Trial
Timeframe: Up to 90 minutes during reinstatement trials in a single day visit
Drinking in Daily Life Assessed With the Ecological Momentary Assessment (EMA)
Timeframe: 22-37 days
Craving in Daily Life Assessed With Event-contingent Ecological Momentary Assessment (EMA)
Timeframe: 22-37 days
Craving in Daily Life Assessed With Random-prompt Ecological Momentary Assessment (EMA)
Timeframe: 22-37 days