Clarithromycin as Adjuvant to Periodontal Debridement

Inclusion Criteria: * diagnosis of Generalized Aggressive Periodontitis * presence of ≥20 teeth * presence of ≥ 6 sites presenting probing depth (PD) ≥5mm with bleeding on probing (BOP) and ≥2 sites with PD ≥7mm (including incisors and first molars, in addition to two other non-contiguous teeth between them) * good general health * \<35 years of age * agree to participate in the study and sign a written consent Exclusion Criteria: * pregnant or lactating * suffering from any other systemic disease (e.g. cardiovascular, diabetes, blood dyscrasias, immunodeficiency, etc) which could alter the course of periodontal disease * received antimicrobials in the previous 6 months * taking long-term anti-inflammatory drugs * received a course of periodontal treatment within the last 12 months * smoked