The purpose of this pharmacodynamic and pharmacokinetic study is to identify a dose of TV-46046 (within the range 80 to 300 mg) that is both safe and consistent with contraceptive effect when injected every 6 months.
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Part 1: Serum Medroxyprogesterone Acetate (MPA) Concentration at Day 1
Timeframe: Day 1
Part 1: Serum MPA Concentration at Day 7
Timeframe: Day 7
Part 1: Serum MPA Concentration at Day 28
Timeframe: Day 28
Part 1: Serum MPA Concentration at Day 91
Timeframe: Day 91
Part 1: Serum MPA Concentration at Day 182
Timeframe: Day 182
Part 1: Serum MPA Concentration at Day 210
Timeframe: Day 210
Part 1: Maximum Observed Serum Concentration (Cmax) of MPA
Timeframe: Day 0 up to Week 52
Part 1: Observed Serum Drug Concentration at Day 182 (C182) of MPA
Timeframe: Day 182
Part 1: Time to Reach Cmax (Tmax) of MPA
Timeframe: Day 0 up to Week 52
Part 1: Area Under the Serum Drug Concentration by Time Curve From Time 0 to Day 182 (AUC0-182) of MPA
Timeframe: Day 0 up to Day 182
Part 1: Area Under the Serum Drug Concentration by Time Curve From Time 0 to Day 210 (AUC0-210) of MPA
Timeframe: Day 0 up to Day 210
Part 1: Area Under the Serum Drug Concentration by Time Curve From Time 0 to Infinity (AUC0-∞) of MPA
Timeframe: Day 0 up to Week 52
Part 1: Apparent Terminal Half-life (t1/2) of MPA
Timeframe: Day 0 up to Week 52
Part 2: Time to Ovulation
Timeframe: Day 0 up to Week 78