Development of a Non-invasive Assessment of Human Bone Quality Using Spatially Offset Raman Spectroscopy

INCLUSION CRITERIA Cohort 1: 40 volunteers, free from bone disease: * Participants must be free from bone disease and not have a family history of OI; * Participants to be age and sex matched with OP participants may be recruited among individuals attending the RNOH Metabolic Unit for DXA scanning, who are shown to have normal bone density T score\> -2.5; * No history of non-accidental fracture; * No history of OA or clinical manifestations of disease; * No clinical features of OI; * Controls will be sex and age matched (within five years) to the disease cohort patients. * Children and adults both required Cohort 2: 40 patients with OI: * Patients must have been clinically diagnosed with OI; * Where possible participants will be identified from the Royal National Orthopaedic Hospital, Metabolic Unit database; if not from RNOH then diagnosis will be otherwise confirmed Cohort 3: 40 patients with OA: * Patients must have been clinically diagnosed with OA; * Participants will be identified from the Royal National Orthopaedic Hospital, Metabolic Unit database; if not from RNOH then diagnosis will be otherwise confirmed Cohort 4: 40 patients with OI, receiving treatment with bisphosphonates: * Patients must have been clinically diagnosed with OI and bisphosphonates prescribed as a course of treatment; * 20 Adults and 20 children * Where possible participants will be identified from the Royal National Orthopaedic Hospital, Metabolic Unit database; if not from RNOH then diag…