L-Citrulline in Patients With Post-Polio Syndrome

Inclusion Criteria: * Prior paralytic poliomyelitis with evidence of motor neuron loss * A period of partial or complete functional recovery after acute paralytic Poliomyelitis * Slowly progressive and persistent new muscle weakness or decreased endurance, with or without generalized fatigue, muscle atrophy, or muscle and joint pain. Symptoms that persist for at least a year * Exclusion of other neuromuscular, medical and skeletal abnormalities as causes of symptoms * Patients older than 18 years at time of Screening * ambulant * ability to walk 150m in the 6 min. Walking distance (6MWD) * females of childbearing potential willing to use contraceptive during the study Exclusion Criteria: * Previous (3 months or less) or concomitant participation in any other therapeutic trial * Use of L-citrulline or L-arginine within the last 3 months * Known individual hypersensitivity to L-citrulline * Known or suspected malignancy * Other chronic disease or clinical relevant limitation of renal, liver, heart function according to discretion of investigator * Pregnant or breast-feeding women * Severe renal failure (calculated glomerular filtration rate (GFR) \< 30 ml/min)