Uveitis is a disease that affects over 2 million people around the globe, and can ultimately lead to blindness. The proportion of patients with uveitis who become blind has not been reduced over the past 30 years, and this is therefore an area that demands further research. One of the major causes of blindness in uveitic patients is the development of uveitic glaucoma, which occurs in 10-20% of uveitic eyes. This is likely to occur for reasons related to the uveitis itself, but can also be caused as a side effect of the corticosteroids used to treat uveitis. The raised IOP in uveitis is more difficult to treat than other types of glaucoma.
To enable more effective treatment of uveitic glaucoma, the investigators need to understand more clearly the mechanisms which underlie this process. The investigators therefore propose a study to examine the contribution of altered aqueous dynamics to the development of raised IOP in uveitis.
Who can participate
Age range18 Years – 90 Years
SexALL
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Inclusion criteria
✓. Patients with idiopathic recurrent anterior uveitis with or without raised IOP.
✓. Normal healthy subjects with no ocular problems (other than refractive error) and IOP at screening \< 21mmHg.
✓. Age \>18 years.
✓. Adequate cognitive function and ability to understand verbal and written information in English.
Exclusion criteria
✕. Other secondary glaucomas including pigment dispersion syndrome and pseudoexfoliation.
✕. Normotensive glaucoma.
✕. Primary angle closure.
✕. Ocular trauma.
✕. Intraocular or keratorefractive surgery.
✕. Use of systemic medication that may affect aqueous humour production such as beta-blockers.
✕
What they're measuring
1
Facility of outflow
Timeframe: day 1 only (study completion)
2
Rate of aqueous flow (measured by fluorophotometry).
Timeframe: Four times during the morning through day 1 only (study completion)