Ataluren for Nonsense Mutation in CDKL5 and Dravet Syndrome (NCT02758626) | Clinical Trial Compass
CompletedPhase 2
Ataluren for Nonsense Mutation in CDKL5 and Dravet Syndrome
United States15 participantsStarted 2016-11
Plain-language summary
This is a phase 2, crossover study of Ataluren for the treatment of nonsense mutation Dravet syndrome or cyclin-dependent kinase-like 5 (CDKL5) deficiency, resulting in drug-resistant epilepsy. Patients will receive 12 weeks of ataluren or placebo during each treatment period. Treatment Period 1 will be followed by a 4-week Washout Period. Based on ataluren PK and pharmacodynamic data, the 4-week washout period is deemed an appropriate length of time to eliminate any ataluren drug effects. Following the Washout Period, patients will crossover to receive the opposite treatment during Treatment Period 2 as follows: Patients receiving ataluren during Treatment Period 1 will receive placebo during Treatment Period 2. Patients receiving placebo during Treatment Period 1 will receive ataluren during Treatment Period 2.
Who can participate
Age range
2 Years – 12 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Age ≥ 2 years old and ≤ 12 years old, male or female, at Week 0 (at time informed consent/assent is signed)
. Documentation of a diagnosis of Dravet syndrome or CDKL5 deficiency resulting from a nonsense mutation in 1 allele, as evidenced by medical records, genetic testing, and the following clinical feature:
. Between 1 to 3 baseline AEDs at stable doses for a minimum for 4 weeks prior to the Baseline visit
. VNS must be on stable settings for a minimum of 3 months prior to the Baseline visit
. If on ketogenic or modified Atkins diet, must be on stable ratio for a minimum of 3 months prior to the Baseline visit
. Written consent obtained from the patient or patient's legal representative must be obtained prior to performing any study procedures
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Percent Change From Baseline in 28-Day Convulsive Seizure Frequency During Ataluren Treatment Period
Timeframe: Baseline, Week 12 of Ataluren Treatment (Up to Week 28)
2
Percent Change From Baseline in 28-Day Convulsive Seizure Frequency During Placebo Treatment Period
Timeframe: Baseline, Week 12 of Placebo Treatment (Up to Week 28)
. Minimum of 6 convulsive or drop seizures with duration \> 3 seconds over the 4 weeks of diary screening prior to randomization and ≥ 6 convulsive or drop seizures with duration \> 3 seconds during the 4 weeks from Screening to Baseline.
Exclusion criteria
. Patient is \< 2 years old or ≥ 12 years old
. Epilepsies associated with genetic disorders other than Dravet syndrome or CDKL5 deficiency
. Patient has Dravet or CDKL5 genetic mutations that are NOT nonsense mutations
. Felbatol has been initiated within the past 12 months prior to the Screening Visit
. Patients who are currently or have participated in clinical trials in the 30 days prior to enrollment (Baseline Visit)
. Prior or ongoing medical condition (eg, concomitant illness, psychiatric condition), medical history, physical findings, or laboratory abnormality that, in the investigator's opinion, could adversely affect the safety of the patient, makes it unlikely that the course of study drug administration or follow-up would be completed, or could impair the assessment of study results.
. Ongoing intravenous administration of aminoglycosides or vancomycin.