Efficacy of Colonoscopy, Colon Capsule and Fecal Immunological Test for Colorectal Cancer Screening

Inclusion criteria: * History of colorectal cancers (any age) in first-degree relatives (parents, children, siblings including half-brothers and sisters) * Age \> or = 45 years * No previous colorectal cancer screening * Informed patient * Patient having signed the consent form * Patient affiliated to a social security system or recipient of such system Exclusion criteria: * Any previous colorectal cancer screening: * History of blood tests in the stool (hemoccult, fecal immunological test, ...) * History of colonic capsule screening * History of colonoscopy * Any known advanced neoplasia or colorectal cancer * Known genetic predisposition to colorectal cancer (very high risk group) * Adults protected by law (under guardianship or trusteeship) * Other metastatic cancers * Life-threatening diseases