Fluoxetine for Visual Recovery After Ischemic Stroke

Inclusion Criteria: * MRI-confirmed acute ischemic stroke resulting in an isolated homonymous visual field loss. Exclusion Criteria: * Known hypersensitivity to fluoxetine or other selective serotonin reuptake inhibitors * National Institutes of Health Stroke Scale score greater than 5 * Premorbid modified Rankin Scale score greater than 2 * Premorbid monocular or binocular visual field deficits * Premorbid retinopathy or optic neuropathy * Premorbid depression * History of cognitive impairment, dementia, or neurodegenerative disorder * History of seizure disorder * History of mania or hypomania * History of hyponatremia * History of angle-closure glaucoma or elevated intraocular pressure * Current alcohol abuse or impaired liver function * Current use of an antidepressant medication * Current use of a medication likely to have an adverse interaction with fluoxetine * Current use of a medication likely to impair post-stroke recovery * Contraindication to MRI * Pregnancy or lactation * Hemorrhagic transformation of the index stroke, resulting in mass effect * Enrollment in another clinical trial at the time of the index stroke