Injectable Cabotegravir Compared to TDF/FTC For PrEP in HIV-Uninfected Men and Transgender Women Who Have Sex With Men

Inclusion Criteria: * MSM and TGW, 18 years or older at the time of screening (male at birth) * Willing to provide informed consent for the study * At high risk for sexually acquiring HIV infection based on self-report of at least one of the following: * Any condomless receptive anal intercourse in the 6 months prior to enrollment (condomless anal intercourse within a monogamous HIV seronegative concordant relationship does not meet this criterion) * More than five partners in the 6 months prior to enrollment (regardless of condom use and HIV serostatus, as reported by the enrollee) * Any stimulant drug use in the 6 months prior to enrollment * Rectal or urethral gonorrhea or chlamydia or incident syphilis in the 6 months prior to enrollment * SexPro score of less than or equal to 16 (U.S. sites only) * In general good health, as evidenced by the following laboratory values, which must be from specimens obtained within 45 days prior to study enrollment: * Non-reactive / negative HIV test results. More information on this criterion can be found in the protocol. * Hemoglobin greater than 11 g/dL, * Absolute neutrophil count greater than 750 cells/mm\^3 * Platelet count greater than or equal to 100,000/mm\^3 * Calculated creatinine clearance greater than or equal to 60 mL/minute using the Cockcroft-Gault equation (use sex at birth for calculation) * Although not protocol exclusionary, sites should carefully consider the advisability of enrolling parti…