Study of Phasix™ Mesh for VHWG Grade 3 Midline Hernia Repair

Inclusion Criteria: * Subject must be diagnosed with incisional midline hernia. * Subject has a VHWG Grade 3 hernia (as defined in the protocol). * Size of hernia ≥ 10 cm2. * Subject must be willing to undergo a planned retro-rectus hernia repair (onlay allowed as an exception when retro-rectus placement cannot be achieved; using absorbable suture) with or without Component Separation Technique. Exclusion Criteria: * Subject with \> 4 previous repairs of the hernia under observation. * Body Mass Index (BMI) \> 35 kg/m2. * The subject is on, or suspected to be placed on, chemotherapy medications during any part of the study. * The subject has peritonitis. * Known human immunodeficiency virus (HIV) infection (if documented in the subject's record). * The subject has cirrhosis of the liver and/or ascites. * Subject is American Society of Anesthesiology Class 4 or 5. * Complete removal of existing mesh from a prior hernia repair (in the same affected area) is not possible. * The hernia repair requires more than a single piece mesh (with adequate overlap beyond the margins of the defect on all sides). * Subject has intact permanent mesh adjacent to the current hernia to be repaired. * Subject's hernia repair requires intraabdominal mesh placement. * Surgical technique requires surgical bridge repair as the sole repair. * Subject has any condition that, in the opinion of the Investigator, would preclude the use of the study device, or preclude the subject from completing the fol…