Glutaminergic Transmission in Autism : Molecular Imaging Exploration
France27 participantsStarted 2016-04
Plain-language summary
Glutamatergic transmission exploration using PET (Positron Emission Tomography) imaging in autism compared to Fragile-X Syndrome ( FXS) and Healthy Volunteers
Who can participate
Age range18 Years ā 45 Years
SexMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Male
* Between 18 years-old and 45 years-old
* Informed, written consent obtained from patient or his representant
* Subject with an affiliation to French social security
* For autistic patient : patient with diagnosis of ASD (Autistic Spectrum Disorders) following DSM-IV or DSM-5 criteria with recommended tools (ADI-R and/or ADOS)
* For FXS patient : diagnosis of FXS and confirmation of total mutation of FMR1
Exclusion Criteria:
* Contraindications to MRI
* Excessive use of alcohol or drug, or addiction to alcohol or drug during last 6 months
* Any unstable or uncontrolled disease, clinically significant
* Participation to an other experimental protocol with drug or irradiant exam
* Person under exclusion period because of previous participation to an other experimental protocol
* Person under temporary guardianship
* Forbidden treatments : any psychotropic treatment for 4 last weeks before PET exam and changing durably glutaminergic transmission directly or undirectly
* For healthy subjects : adult under guardianship, medical history of central nervous system disease, medical history of attention deficit hyperactivity disorder, past or present psychiatric or neurologic disorder (MINI DSM-IV)
What they're measuring
1
cerebral glutaminergic activity assessed by binding potential of [18F]FPEB