CompletedNot Applicable

Propofol Pharmacokinetics and Pharmacodynamics Modelling

Portugal60 participantsStarted 2016-04-01

Plain-language summary

The main purpose of this research is to develop a population pharmacokinetic and pharmacodynamic model of Propofol when used for induction and maintenance of anaesthesia, using BIS as a pharmacodynamic endpoint. A covariate analysis will be performed in order to account for variability in pharmacokinetic and pharmacodynamic parameters. The influence of age and obesity on propofol pharmacokinetic parameters will be particularly addressed.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adult patients admitted for nose or ear surgery, bariatric surgery or urgent orthopaedic surgery. Exclusion Criteria: * Severe hepatic or renal insufficiency; * Significant haemodynamic instability previous to the surgery; * Allergy to eggs or propofol at the time of enrolment; * Predictive criteria for difficult airway management.

What they're measuring

Plasma Propofol Concentration (mcg/mL)

Timeframe: up to 2 hours

Trial details

NCT IDNCT02713698

SponsorCentro Hospitalar do Porto

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2017-04

Results submitted2018-01-24

View on ClinicalTrials.gov More Intravenous Anesthetic Agent Overdose trials